CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

International Journal of Molecular Sciences

Ke-Tai Guo¹  Angela Paul¹  Christian Schichor²  Gerhard Ziemer¹ 

[1] Department of Thoracic, Cardiac and Vascular surgery, University Hospital Tuebingen, Calwerstr.7/1, D72076 Tuebingen, Germany;Department of Neurosurgery, Ludwig-Maximilians-University, Klinikum Grosshadern, Marchioninistr. 15, D81377 Munich, Germany

关键词: cell-SELEX;    aptamer;    nanotechnology;   

DOI  :  10.3390/ijms9040668

来源: mdpi

【 摘 要 】

Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.

【 授权许可】

CC BY   
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