The Influence of Hofmeister Series Ions on Hyaluronan Swelling and Viscosity

Molecules

Aleš Mráპk¹  Júlia Varhaníková¹  Marián Lehocký²  Lenka Gřundělová¹  Alena Pokopcová¹ 

[1] Department of Physics and Materials Engineering, Faculty of Technology, Tomas Bata University in Zlín, Nad Stráněmi 4511, 76005 Zlín, Czech Republic; E-mails:;Medical Materials Research Centre, Technology park, University Institute, Tomas Bata University in Zlín, Nad Ovcirnou III 3685, Zlín, 76001 Czech Republic; E-mail:

关键词: Material Science;    biomaterials;    hyaluronan;    Hofmeister series;   

DOI  :  10.3390/molecules13051025

来源: mdpi

【 摘 要 】

The dissolution of hyaluronan in water leads to its degradation, and as a result its molecular weight decreases. The degradation of hyaluronan is mainly influenced by temperature, solution composition, and also its pH. This study describes the influence of Hofmeister series ions on hyaluronan behaviour and hyaluronan film swelling by solutions of these ions. It was found that Hofmeister ions show lyotropic effects influencing the entanglement of hyaluronan coils and their expansion from solid polymer films into swollen gel state. The hydrophobic and hydrophilic interactions in the structure of hyaluronan macromolecules are represented by the mutual diffusion coefficient D(c), the mean mutual diffusion coefficient D_s, the expansion work of coil swelling RA_δ,s, the activation enthalpy of diffusion connected with swelling H_D,s and kinematic viscosity of hyaluronan-ions solutions ν.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.