The Antioxidant Response Induced by Lonicera caerulaea Berry Extracts in Animals Bearing Experimental Solid Tumors

Molecules

Maria Iuliana Gruia³  Eliza Oprea¹  Ion Gruia²  Valentina Negoita³ 

[1] University of Bucharest, Faculty of Chemistry, 4-12 Regina Elisabeta, 030018, Bucharest, Romania;University of Bucharest, Faculty of Physics, MG-11 Magurele, 077125, Bucharest, Romania;Institute of Oncology Bucharest, 252 Fundeni, 022338, Bucharest, Romania

关键词: Antioxidant;    Lonicera caerulaea;    experimental tumors;    lipid peroxidation;    ceruloplasmin;    thiol groups;   

DOI  :  10.3390/molecules13051195

来源: mdpi

【 摘 要 】

Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentally-induced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.