Sensors | |
Fluorescent Indolizine-β-Cyclodextrin Derivatives for the Detection of Volatile Organic Compounds | |
Matthieu Becuwe1  David Landy1  François Delattre1  Francine Cazier1  | |
[1] id="af1-sensors-08-03689">Laboratoire de Synthèse Organique et Environnement (EA 2599), 145 Avenue Maurice Schumann, 59140 Dunkerque, Fran | |
关键词: Indolizine-β-cyclodextrin; sensor; formation constants; docking; sensing capabilities; detection; Volatile Organic Compounds; | |
DOI : 10.3390/s8063689 | |
来源: mdpi | |
【 摘 要 】
This paper presents the synthesis, the structural determination and the sensing capabilities toward Volatile Organic Compounds (VOCs) of a new class of fluorescent indolizine-cyclodextrin sensors. Two different pathways, both involving bipyridinium ylides and 6-amino-b-cyclodextrin, have been used to carry out the synthesis of these sensors. The macrocycle structures were dominantly established by 1H-NMR spectra and systematically studied by molecular modelling (MM3, AM1, AM1-COSMO methods). The sensing capabilities of the sensors were evaluated by emission of fluorescence, during the inclusion of the guest (adamantanol or aromatic derivatives) into the cyclodextrin (CD) host cavity. The host/guest complex formation was investigated by formation constant determinations, using experimental methods, coupled with theoretical calculations of formation energies using a specific docking procedure. Both experimental and theoretical results suggest that some compounds would make very attractive sensors for VOC detection. Some compounds could also be taken into consideration as biological markers.
【 授权许可】
CC BY
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190058900ZK.pdf | 609KB | download |