Antioxidant Capacity and In Vitro Prevention of DentalPlaque Formation by Extracts and Condensed Tannins of Paullinia cupana

Molecules

Elza Yamaguti-Sasaki²  Lia Akina Ito¹  Vanessa Cristina Dias Canteli¹  Tânia Mara Antonelli Ushirobira³  Tânia Ueda-Nakamura²  Benedito Prado Dias Filho²  Celso Vataru Nakamura² 

[1] Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringá, Av. Colombo, 5790, BR-87020-900, Maringá, PR, Brazil;Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Av. Colombo, 5790, BR-87020-900, Maringá, PR, Brazil;CCAS, Pontifícia Universidade Católica, Av. Tiradentes, 963, BR-87013-260, Maringá, PR, Brazil

关键词: Paullinia cupana;    methylxanthines;    condensed tannins;    antioxidant capacity;    prevention of the formation of dental plaque;   

DOI  :  10.3390/12081950

来源: mdpi

【 摘 要 】

Chemical evaluation of the semi-purified fraction from the seeds of guaraná, Paullinia cupana H.B.K. var. sorbilis (Mart.) Ducke, yielded the following compounds: caffeine, catechin, epicatechin, ent-epicatechin, and procyanidins B₁, B₂, B₃, B₄, A₂, and C₁. Measurement of the antioxidant activity by reduction of the DPPH radical confirmed the anti-radical properties of the aqueous (AqE) and crude (EBPC) extracts and semi-purified (EPA and EPB) fractions. The EPA fraction showed radical-scavenging activity (RSA) and protected DPPH from discoloration at 5.23±0.08 (RSD%=1.49) µg/mL, and for the phosphomolybdenum complex showed a higher Relative Antioxidant Capacity (RAC) at 0.75±0.01 (1.75). The EPA fraction had a total polyphenolics content of 65.80%±0.62 (RSD%=0.93). The plant drug showed 5.47% ± 0.19 (RSD%=3.51) and 6.19% ± 0.08 (RSD%=1.29) for total polyphenolics and methylxanthines, respectively. In vitro assessment of the antibacterial potential of the Paullinia cupana extracts against Streptococcus mutans showed that these could be used in the prevention of bacterial dental plaque.

【 授权许可】

Unknown   
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