New Polyhydroxylated Furostanol Saponins with Inhibitory Action against NO Production from Tupistra chinensis Rhizomes

Molecules

Lan-Lan Xu¹  Kun Zou¹  Jun-Zhi Wang¹  Jun Wu¹  Yuan Zhou¹  Fei-Jun Dan¹ 

[1] ¹Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, P.R. China ²Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.R. China

关键词: Furostanol Saponins;    Tupistra chinensis Bak.;    Liliaceae;    Convallarieae;    NO;   

DOI  :  10.3390/12082029

来源: mdpi

【 摘 要 】

Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5β-furost-δ²⁵⁽²⁷⁾-en-1β,2β,3β,4β,5β,7α,22ξ,26- octaol-6-one-26-O-β-D-glucopyranoside (1) and 5β-furost-δ²⁵⁽²⁷⁾-en-1β,2β,3β,4β,5β,6β, 7α,22ξ,26-nonaol-26-O-β-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 μg/mL.

【 授权许可】

CC BY   
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