Mechanosensor Channels in Mammalian Somatosensory Neurons

Sensors

Matthieu Raoux¹  Lise Rodat-Despoix¹  Nathalie Azorin¹  Aurélie Giamarchi¹  Jizhe Hao¹  François Maingret¹  Marcel Crest¹  Bertrand Coste¹ 

[1] id="af1-sensors-07-01667">Laboratoire de Neurophysiologie Cellulaire, Centre National de la Recherche Scientifique UMR 6150, Université de la Méditerranée, Marseille, Fran

关键词: Pain;    Touch;    Skin sensation;    Mechanosensory transduction;    Stretch;    Osmotic shock;    Mechanosensitive channels;    TRP channels;    ASIC;    amiloride;    DRG;   

DOI  :  10.3390/s7091667

来源: mdpi

【 摘 要 】

Mechanoreceptive sensory neurons innervating the skin, skeletal muscles and viscera signal both innocuous and noxious information necessary for proprioception, touch and pain. These neurons are responsible for the transduction of mechanical stimuli into action potentials that propagate to the central nervous system. The ability of these cells to detect mechanical stimuli impinging on them relies on the presence of mechanosensitive channels that transduce the external mechanical forces into electrical and chemical signals. Although a great deal of information regarding the molecular and biophysical properties of mechanosensitive channels in prokaryotes has been accumulated over the past two decades, less is known about the mechanosensitive channels necessary for proprioception and the senses of touch and pain. This review summarizes the most pertinent data on mechanosensitive channels of mammalian somatosensory neurons, focusing on their properties, pharmacology and putative identity.

【 授权许可】

Unknown   
© 2007 by MDPI (http://www.mdpi.org).