期刊论文详细信息
Sensors
D-galactose/D-glucose-binding Protein from Escherichia coli as Probe for a Non-consuming Glucose Implantable Fluorescence Biosensor
Viviana Scognamiglio1  Vincenzo Aurilia1  Nunzio Cennamo2  Paola Ringhieri1  Luisa Iozzino1  Micaela Tartaglia1  Maria Staiano1  Giuseppe Ruggiero1  Pierangelo Orlando1  Tullio Labella1  Luigi Zeni2  Annalisa Vitale1 
[1] Laboratory for Molecular Sensing, IBP, CNR, Via Pietro Castellino, 111 80131 Naples, Italy;Department of Information Engineering, Seconda Università di Napoli, Italy
关键词: Biosensor;    Optical sensing;    Glucose;    Diabetes;    Fluorescence;    Proteins;   
DOI  :  10.3390/s7102484
来源: mdpi
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【 摘 要 】

D-Galactose/D-glucose-binding protein from E. coli (GGBP) is a monomer that binds glucose with high affinity. The protein structure of GGBP is organized in two principal domains linked by a hinge region that form the sugar-binding site. In this work we show that the mutant form of GGBP at the amino acid position 182 can be utilized as a probe for the development of a non-consuming analyte fluorescence biosensor to monitor the glucose level in diabetes health care.

【 授权许可】

Unknown   
© 2007 by MDPI (http://www.mdpi.org).

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