Modelling a Peroxidase-based Optical Biosensor

Sensors

Romas Baronas¹  Evelina Gaidamauskaite¹ 

[1] Department of Software Engineering, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania; E-mail:

关键词: optical biosensor;    peroxidase;    modelling;    simulation;   

DOI  :  10.3390/s7112723

来源: mdpi

【 摘 要 】

The response of a peroxidase-based optical biosensor was modelled digitally. A mathematical model of the optical biosensor is based on a system of non-linear reaction-diffusion equations. The modelling biosensor comprises two compartments, an enzyme layer and an outer diffusion layer. The digital simulation was carried out using finite difference technique. The influence of the substrate concentration as well as of the thickness of both the enzyme and diffusion layers on the biosensor response was investigated. Calculations showed complex kinetics of the biosensor response, especially at low concentrations of the peroxidase and of the hydrogen peroxide.

【 授权许可】

Unknown   
© 2007 by MDPI (http://www.mdpi.org).