Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women

International Journal of Environmental Research and Public Health

J. L. Ble-Castillo⁴  G. Cleva-Villanueva³  J. C. D໚z-Zagoya²  R. Medina-Santillán³  H. O. Rubio-Arias¹ 

[1] Faculty of Zootechnic, Autonomous University of Chihuahua, Mexico;Research Station in DACS, Juarez Autonomous University of Tabasco, Ave. Universidad No 2890, Colonia Tamulte, Villahermosa Tabasco, C.P. 86100, México;Superior Medicine School of the National Polytechnic Institute, México, D.F., México;General Hospital, Zone 46, IMSS, Prolongación de Avenida Universidad Km 2.5, Colonia Casa Blanca, 86060, Villahermosa, Tabasco, México

关键词: α-tocopherol;    oxidative stress;    lipid peroxidation;    overweight;   

DOI  :  10.3390/ijerph200704040001

来源: mdpi

【 摘 要 】

Despite extensive research, the effects of α-tocopherol supplementation remain controversial. Few studies have been focused on obese and overweight people. We examined the effects of α-tocopherol (AT) on the oxidative status and metabolic profile in overweight women. Sixteen overweight women between the ages of 40–60 years old, received AT, 800 IU/day during 12 weeks, followed by a 6-week washout period. Blood samples were taken at the beginning and then every 6 weeks until the end of the study. AT, retinol, malondialdehyde (MDA), total antioxidant status (TAS), selenium-dependent glutathione peroxidase (GPx) and CuZn-superoxide dismutase (SOD) were quantified to evaluate the oxidative stress. The metabolic profile was estimated by measuring glycated hemoglobin (HbA1c) in erythrocytes and glucose, phosphate, magnesium, lipid and lipoprotein concentrations in serum. Under AT administration HbA1c, serum-MDA levels and erythrocyte GPx activity were markedly reduced. TAS, AT and Mg²⁺ concentrations in serum and SOD activity in erythrocytes were higher after AT treatment. Body weight; glucose, lipid and retinol concentrations, or blood cells count were unchanged. Lipid peroxidation was considerably reduced in AT treated women and also improved serum antioxidant status was observed, but the imbalanced response between erythrocyte SOD and GPx activities could affect normal response to oxidative stress.

【 授权许可】

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