Synthesis and Structural Analysis of Polyester Prodrugs of Norfloxacin

Molecules

Marcin Sobczak¹  Ewa Witkowska²  Ewa Olᆝzka² 

[1] Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warsaw, Poland; E-mails

关键词: aliphatic polyesters;    ring-opening polymerization;    macromolecular prodrugs;    prodrugs of norfloxacin;   

DOI  :  10.3390/molecules13010096

来源: mdpi

【 摘 要 】

Two-, three- and four-arm, star-shaped poly(ε-caprolactone) and poly(D,L‑lactide) homopolymers, and copolymers of ε-caprolactone with D,L-lactide were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. Thus obtained oligomers were successfully used in the synthesis of novel macromolecular prodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated by means of MALDI-TOF MS, NMR and IR studies. 

【 授权许可】

Unknown   
© 2008 by MDPI (http://www.mdpi.org).