Dietary Flavonoids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

International Journal of Molecular Sciences

Ewelina Szliszka¹  Zenon P. Czuba¹  Katarzyna Jernas¹ 

[1] id="af1-ijms-09-00056">Chair and Department of Microbiology and Immunology, Jordana 19, 41 808 Zabrze, Medical University of Silesia, Katowice, Poland, Tel. / Fax: [phone]

关键词: Dietary flavonoids;    TRAIL;    HeLa;    chemoprevention;    antitumoral activity;   

DOI  :  10.3390/ijms9010056

来源: mdpi

【 摘 要 】

TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.

【 授权许可】

CC BY   
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