Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A2A Receptor Antagonist MSX-2

Molecules

Karl Vollmann¹  Ramatullah Qurishi¹  Jörg Hockemeyer¹ 

[1] id="af1-molecules-13-00348">Pharma-Center Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, An der Immenburg 4, D-53121 Bonn, Germany; http://www.pharmazentrum.uni-bonn.de/ and http://www.pharma.uni-bonn.de/pharmchem/

关键词: Prodrug;    adenosine receptor antagonist;    MSX-4;    water-solubility;    Parkinson’s disease;    esterase;   

DOI  :  10.3390/molecules13020348

来源: mdpi

【 摘 要 】

The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargyl­xan­thine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an amino acid ester prodrug of the adenosine A_2A receptor antagonist MSX-2. It was found to be stable in artificial gastric acid, but readily cleaved by pig liver esterase.

【 授权许可】

Unknown   
© 2008 by MDPI (http://www.mdpi.org).