Design, Synthesis and Applications of HyaluronicAcid-Paclitaxel Bioconjugates†

Molecules

Francesca Leonelli¹  Angela La Bella¹  Luisa Maria Migneco¹ 

[1]Dipartimento di Chimica and Istituto di Chimica Biomolecolare del CNR, Sezione di Roma, Università degli Studi di Roma "La Sapienza”, P.le Aldo Moro 5, BOX n. 34 ROMA 62, I-00185 Roma, Italy

[2] E-mails

关键词: Paclitaxel;    Hyaluronic Acid;    Hyaluronic Acid-Paclitaxel Bioconjugate;    Synthesis;    Biological Activity;   

DOI  :  10.3390/molecules13020360

来源: mdpi

【 摘 要 】

Paclitaxel (1a), a well known antitumor agent adopted mainly for the treatment of breast and ovarian cancer, suffers from significant disadvantages such as low solubility, certain toxicity and specific drug-resistance of some tumor cells. To overcome these problems extensive research has been carried out. Among the various proposed strategies, the conjugation of paclitaxel (1a) to a biocompatible polymer, such as hyaluronic acid (HA, 2), has also been considered. Coupling a bioactive compound to a biocompatible polymer offers, in general, many advantages such as better drug solubilization, better stabilization, specific localization and controlled release. Hereafter the design, synthesis and applications of hyaluronic acid-paclitaxel bioconjugates are reviewed. An overview of HA-paclitaxel combinations is also given.

【 授权许可】

Unknown   
© 2008 by MDPI (http://www.mdpi.org).