Molecules | |
Novel Prodrugs for Targeting Diagnostic and Therapeutic Radionuclides to Solid Tumors | |
Amin I. Kassis1  Houari Korideck2  Ketai Wang2  Pavel Pospisil2  | |
[1]id="af1-molecules-13-00391">Radiology, Harvard Medical School, Armenise Building, Room D2-137, 200 Longwood Avenue, Boston, Massachusetts 02115, U | |
关键词: Prodrug; solid tumors; radioiodine; radioimaging; radiotherapy; | |
DOI : 10.3390/molecules13020391 | |
来源: mdpi | |
【 摘 要 】
Most cancer therapeutics (chemo, radiation, antibody-based, anti-angiogenic) are at best partially and/or temporarily effective. In general, the causes for failure can be summarized as: (i) poor diffusion and/or nonuniform distribution of drug/prodrug molecules in solid tumors; (ii) high drug concentration and retention in normal tissues (leading to side effects); (iii) requirement for plasma-membrane permeability and/or internalization of drug/prodrug molecules; (iv) low uptake of drug by tumor; (v) lack of retention of drug within tumor (most have
【 授权许可】
Unknown
© 2008 by MDPI (http://www.mdpi.org).
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190058507ZK.pdf | 639KB | download |