Regioselective Synthesis of 1-(2,6-Dichloro-4-Trifluoromethyl-phenyl)-4-Alkyl-1H-[1,2,3]-Triazoles

Molecules

Huanan Hu²  Anjiang Zhang¹  Lisheng Ding²  Xinxiang Lei¹ 

[1] College of Chemistry and Material Engineering, Wenzhou University, Wenzhou 325027, P. R. China;Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China

关键词: 1;    3-Dipolar cycloaddition;    1;    2;    3-triazole;    internal alkyne;    regioselective;   

DOI  :  10.3390/molecules13030556

来源: mdpi

【 摘 要 】

A new and efficient method for the synthesis of 1-(2,6-dichloro-4-trifluoro-methylphenyl)-4-alkyl-1H-[1,2,3]-triazoles by the room temperature 1,3-dipolar cycloaddition of (2-azido-1,3-dichloro-5-trifluoromethyl)benzene with terminal alkynes in the presence of Cu (I) salt as catalyst is reported. All the reactions gave 1,4-disubstituted products with high regioselectivity, as no 1,5-disubstituted product was formed. The structures of all the title compounds have been confirmed by elemental analysis, ¹H- and ¹³C-NMR and in addition, the structure of compound 5a was investigated by X-ray crystallography.

【 授权许可】

Unknown   
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