Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst

Molecules

Ibrahim Mustafa El-Deeb¹  Jae Chun Ryu² 

[1] Department of Biomolecular Science, University of Science and Technology, Daejon, Korea; E-mail:;Life Sciences Research Division, Korea Institute of Science & Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea; E-mail:

关键词: Palladium catalyst;    N-arylation;    aminopyrimidine;    xantphos;    Suzuki coupling;    Buchwald-Hartwig amination;   

DOI  :  10.3390/molecules13040818

来源: mdpi

【 摘 要 】

New N-aryl-4-(pyridin-3-yl)pyrimidin-2-amine derivatives were synthesized from the corresponding amines, applying optimized Buchwald-Hartwig amination conditions using dichlorobis(triphenylphosphine)Pd(II), xantphos and sodium tert-butoxide in refluxing toluene under a nitrogen atmosphere. The target N-aryl derivatives were obtained in moderate to good yields ranging from 27% to 82%. The procedure described could be widely employed for the preparation of new heterocyclic compounds. The structures of the new compounds were confirmed by FT-NMR, FT-IR and elemental analysis.

【 授权许可】

Unknown   
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