Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida

Molecules

Shou-Fang Wu²  Pei-Wen Hsieh²  Chin-Chung Wu²  Chia-Lin Lee²  Shu-Li Chen²  Chi-Yu Lu³  Tian-Shung Wu¹  Fang-Rong Chang² 

[1] Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan; E-mail:;Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-mails:;Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan

关键词: Nothapodytes foetida;    9-methoxy-18;    19-dehydrocamptothecin;    5-hydroxy-mappicine-20-O-β-glucopyranoside;    camptothecin;    cytotoxicity;   

DOI  :  10.3390/molecules13061361

来源: mdpi

【 摘 要 】

Two new alkaloids, 9-methoxy-18,19-dehydrocamptothecin (1) and 5-hydroxymappicine-20-O-β-glucopyranoside (2a/2b as a racemic mixture), together with nine known compounds: camptothecin (3), 9-methoxy-camptothecin (4), 5-hydroxy-camptothecin (5a/5b racemic mixture), 5-hydroxy-9-methoxycamptothecin (6a/6b racemic mixture), diosmetin (7), apigenin (8), apigenin-7-O-glucopyranoside (9), rosin (cinnamyl-O-β-D-glucopyranoside) (10) and amarantholidoside IV (11) were isolated from the immature seeds of Nothapodytes foetida (Wight) Sleumer. The structures were elucidated by spectroscopic analyses. In the present research, compounds 1, 3, 4, 5a/5b and 6a/6b, also showed in vitro cytotoxicity against six cancer cell lines (HepG2, Hep3B, MDA-MB-231, MCF-7, A549, and Ca9-22). Among them, compound 1 exhibited significant cytotoxicity against these cancer cell lines, with IC₅₀ of 0.24-6.57 μM. Furthermore, HPLC profiles were developed for qualitative and quantitative analysis of these active constituents in different parts of this plant, including mature and immature seeds, leaves, stems and roots. The results revealed that compounds 3 and 4 have the highest concentrations, which are found in the roots part of the plant.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.