Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes

Sensors

Olga Domínguez-Renedo¹  M. Encarnación Burgoa Calvo¹ 

[1] Departamento de Química, Área de Química Analítica, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001 Burgos, Spain;

关键词: lamotrigine;    screen-printed electrodes;    differential pulse adsorptive stripping voltammetry;   

DOI  :  10.3390/s8074201

来源: mdpi

【 摘 要 】

This paper describes a procedure that has been optimized for the determination of lamotrigine by Differential Pulse Adsorptive Stripping Voltammetry (DPAdSV) using carbon screen-printed electrodes (CSPE) and mercury coated carbon screen-printed electrodes. Selection of the experimental parameters was made using experimental design methodology. The detection limit found was 5.0 × 10^-6 M and 2.0 × 10^-6 M for the non modified and Hg modified CSPE, respectively. In terms of reproducibility, the precision of the above mentioned methods was calculated in %RSD values at 9.83% for CSPE and 2.73% for Hg-CSPE. The Hg-coated CSPEs developed in this work were successfully applied in the determination of lamotrigine in pharmaceutical preparations.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.