Bioactive Pentacyclic Triterpenes from the Stems of Combretum laxum

Molecules

Eder Bisoli¹  Walmir Silva Garcez¹  Lidilhone Hamerski¹  Caroline Tieppo¹ 

[1] Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil, 79070-900; E-mails

关键词: Combretum laxum;    Combretaceae;    triterpenes;    antifungal activity;   

DOI  :  10.3390/molecules13112717

来源: mdpi

【 摘 要 】

Two new triterpene glucosides, β-d-glucopyranosyl 2α,3β,24-trihydroxyolean-12-en-28-oate and β-d-glucopyranosyl 2α,3β,23,24-tetrahydroxyurs-12-en-28-oate, in addition to nine known compounds belonging to three different triterpene classes (oleanane-, ursane- and lupane-type) have been isolated from the stems of a specimen of Combretum laxum growing in the “Pantanal” of the central-western region of Brazil. Among the known triterpenes, β-d-glucopyranosyl 2α,3β,6β-trihydroxyolean-12-en-28-oate is reported for the first time in the Combretaceae, while bellericoside and asiatic acid are described for the first time in the genus Combretum. The structures of the isolated compounds have been established on the basis of spectral techniques (1D-, 2D-NMR and MS). Their in vitro antifungal activities against standard strains of Candida albicans, C. krusei and Cryptococcus neoformans were also evaluated in this work.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.