Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

Materials

Georg Sydow-Plum¹  Ziyad S. Haidar¹  Yahye Merhi² 

[1] Department of Biomedical Engineering, Faculty of Medicine, McGill University, 3775 Rue University, Lyman Duff Medical Sciences Building, 3^rd floor, Montréal (Québec), H3A 2B4, Canada. E-mail:;Institut de Cardiologie de Montréal, 5000 Rue Belanger Est, Montréal (Québec) H1T 1C8 Canada. E-mail:

关键词: Chitosan;    controlled drug release;    hyaluronic acid;    polyethylene oxide;    Paclitaxel;    restenosis;    stent;    thrombogenecity.;   

DOI  :  10.3390/ma1010025

来源: mdpi

【 摘 要 】

Membrane-covered Express^2TM Monorail^® stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.