International Journal of Molecular Sciences | |
Detection of FLT3 Oncogene Mutations in Acute Myeloid Leukemia Using Conformation Sensitive Gel Electrophoresis | |
Mamdooh Gari2  Adel Abuzenadah2  Adeel Chaudhary2  Mohammed Al-Qahtani2  Huda Banni2  Waseem Ahmad2  Fatin Al-Sayes1  Sahira Lary3  | |
[1] Hematology Department, Faculty of Medicine, King Abdulaziz University- Jeddah, Kingdom of Saudi Arabia. E-Mails:;Medical Technology Department, Faculty of Applied Medical Sciences, Genomic Medicine Unit, Center of Excellence of Genomic Research. P. O. Box 80216, King Abdulaziz University-Jeddah, Kingdom of Saudi Arabia. E-Mails:;Biochemistry Department, Faculty of Sciences, King Abdulaziz University- Jeddah, Kingdom of Saudi Arabia. E-Mail: | |
关键词: AML; Flt3; ITD; CSGE; Mutational analysis; | |
DOI : 10.3390/ijms9112194 | |
来源: mdpi | |
【 摘 要 】
FLT3 (fms-related tyrosine kinase 3) is a receptor tyrosine kinase class III that is expressed on by early hematopoietic progenitor cells and plays an important role in hematopoietic stem cell proliferation, differentiation and survival. FLT3 is also expressed on leukemia blasts in most cases of acute myeloid leukemia (AML). In order to determine the frequency of FLT3 oncogene mutations, we analyzed genomic DNA of adult
【 授权许可】
CC BY
© 2008 by MDPI
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