Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection

Marine Drugs

Beatriz Paz¹  Antonio H. Daranas¹  Patricia G. Cruz¹  José M. Franco¹  Manuel Norte¹ 

[1] ¹Fitoplancton Tóxico, Instituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36080 Vigo and Instituto Español de Oceanografía, Centro Oceanográfico de Vigo (IEO), Cabo Estay, 36200 Vigo, Spain

关键词: Marine toxins;    DSP;    19-epi-okadaic acid;    Prorocentrum belizeanum;    LC-MS;   

DOI  :  10.3390/md6030489

来源: mdpi

【 摘 要 】

Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC–MS/MS).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.