Broad-Spectrum Drugs Against Viral Agents

International Journal of Molecular Sciences

Mary E. Christopher¹ 

关键词: CpG;    cytokine;    influenza;    poly (ICLC);    TLR;   

DOI  :  10.3390/ijms9091561

来源: mdpi

【 摘 要 】

Development of antivirals has focused primarily on vaccines and on treatments for specific viral agents. Although effective, these approaches may be limited in situations where the etiologic agent is unknown or when the target virus has undergone mutation, recombination or reassortment. Augmentation of the innate immune response may be an effective alternative for disease amelioration. Nonspecific, broad-spectrum immune responses can be induced by double-stranded (ds)RNAs such as poly (ICLC), or oligonucleotides (ODNs) containing unmethylated deocycytidyl-deoxyguanosinyl (CpG) motifs. These may offer protection against various bacterial and viral pathogens regardless of their genetic makeup, zoonotic origin or drug resistance.

【 授权许可】

CC BY   
© 2008 by MDPI