Integration of Motor Proteins – Towards an ATP Fueled Soft Actuator

International Journal of Molecular Sciences

Akira Kakugo¹  Kazuhiro Shikinaka¹ 

[1] id="af1-ijms-09-01685">Graduate School of Science, Hokkaido University, Sapporo 060-0810, Jap

关键词: Biological motors;    self-assembly;    hierarchical structure;    soft-bio-machine;   

DOI  :  10.3390/ijms9091685

来源: mdpi

【 摘 要 】

We present a soft bio-machine constructed from biological motors (actin/myosin). We have found that chemically cross-linked polymer-actin complex gel filaments can move on myosin coated surfaces with a velocity as high as that of native F-actin, by coupling to ATP hydrolysis. Additionally, it is shown that the velocity of polymer-actin complex gel depends on the species of polycations binding to the F-actins. Since the design of functional actuators of well-defined size and morphology is important, the structural behavior of polymer-actin complexes has been investigated. Our results show that the morphology and growth size of polymer-actin complex can be controlled by changes in the electrostatic interactions between F-actins and polycations. Our results indicate that bio actuators with desired shapes can be created by using a polymer-actin complex.

【 授权许可】

CC BY   
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