Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants

Sensors

Eui Tae Kim¹  Jong-Mo Seo¹  Se Joon Woo²  Jing Ai Zhou¹  Hum Chung² 

[1] School of Electrical Engineering and Computer Science; E-Mails:;Department of Ophthalmology, College of Medicine and Seoul Artificial Eye Center, Nano Bioelectronics & System Research Center (NBS-ERC), Seoul National University, Seoul, Korea; E-Mails:

关键词: Polyimide;    retinal implant;    pillar;    optical coherence tomography;    electrically evoked cortical potential;   

DOI  :  10.3390/s8095845

来源: mdpi

【 摘 要 】

Polyimide has been widely applied to neural prosthetic devices, such as the retinal implants, due to its well-known biocompatibility and ability to be micropatterned. However, planar films of polyimide that are typically employed show a limited ability in reducing the distance between electrodes and targeting cell layers, which limits site resolution for effective multi-channel stimulation. In this paper, we report a newly designed device with a pillar structure that more effectively interfaces with the target. Electrode arrays were successfully fabricated and safely implanted inside the rabbit eye in suprachoroidal space. Optical Coherence Tomography (OCT) showed well-preserved pillar structures of the electrode without damage. Bipolar stimulation was applied through paired sites (6:1) and the neural responses were successfully recorded from several regions in the visual cortex. Electrically evoked cortical potential by the pillar electrode array stimulation were compared to visual evoked potential under full-field light stimulation.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.