Efficient TCT-catalyzed Synthesis of 1,5-Benzodiazepine Derivatives under Mild Conditions

Molecules

Chun-Wei Kuo¹  Chun-Chao Wang¹  Veerababurao Kavala¹ 

[1] id="af1-molecules-13-02313">Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 116, Taiwan, R

关键词: Benzodiazepines;    2;    4;    6-trichloro-1;    3;    5-triazine;    enolizable ketones;    o-phenylenediamines;   

DOI  :  10.3390/molecules13092313

来源: mdpi

【 摘 要 】

2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.