Methyl Mercapturate Synthesis: An Efficient, Convenient and Simple Method

Molecules

Benoît Cossec¹  Frຝéric Cosnier² 

[1] id="af1-molecules-13-02394">Institut National de Recherche et de Sécurité, Département Polluants et Santé, Rue du Morvan CS 60027, Vandoeuvre, 54519 cedex, Fran

关键词: Mercapturic acids;    Sulfa-Michael addition;    Phase Transfer Catalysis;    Biomarker;   

DOI  :  10.3390/molecules13102394

来源: mdpi

【 摘 要 】

A safe and simple method for methyl S-arylmercapturate synthesis is described. Thirteen such compounds, to be used afterwards in metabolism studies, have been obtained with yields ranging from 71 to 99.6%. These compounds were obtained using a sulfa-Michael addition and synthesized by adding the corresponding thiophenols to a mixture composed of methyl 2-acetamidoacrylate (MAA), potassium carbonate and a phase transfer catalyst, Aliquat 336. MAA, the initial synthon, was itself isolated in quasi quantitative yield following a fully described synthesis.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.