Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives

Molecules

Hanan Georgey¹  Nagwa Abdel-Gawad² 

[1] Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, Cairo 11562, Egypt; E-mails

关键词: Quinazolin-4-(3H)-ones;    piperazines;    chloroacetamide;    anticonvulsant activity;   

DOI  :  10.3390/molecules13102557

来源: mdpi

【 摘 要 】

A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, ¹H-NMR, MS). A preliminary evaluation of the anticonvulsant properties of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to a diazepam standard.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.