Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review

Molecules

Heloina de Sousa Falcão¹  Jacqueline Alves Leite¹  José Maria Barbosa-Filho¹  Petrônio Filgueiras de Athayde-Filho¹  Maria Célia de Oliveira Chaves¹  Marcelo Dantas Moura¹  Anderson Luiz Ferreira²  Ana Beatriz Albino de Almeida²  Alba Regina Monteiro Souza-Brito²  Margareth de Fátima Formiga Melo Diniz¹ 

[1] Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba - UFPB, Cx. Postal 5009, 58051-970, João Pessoa, PB, Brazil; E-mail:;Laboratório de Produtos Naturais, Universidade Estadual de Campinas - UNICAMP, Cx. Postal 6109, 13083-970, Campinas, SP, Brazil; E-mails:

关键词: Alkaloids;    Antiulcer activity;    Peptic ulcer;    Review.;   

DOI  :  10.3390/molecules13123198

来源: mdpi

【 摘 要 】

Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals.

【 授权许可】

CC BY   
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.