Structure-Activity Relationship of Flavonoids Active Against Lard Oil Oxidation Based on Quantum Chemical Analysis

Molecules

Ji-Guo Yang¹  Ben-Guo Liu³  Gui-Zhao Liang² 

[1] College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, P. R. China; E-mail:;College of Bioengineering, Chongqing University, Chongqing 400044, P. R. China; E-mail:;School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, P. R. China

关键词: Flavonoid;    Structure-Activity Relationship;    Quantum Chemistry;    Antioxidant.;   

DOI  :  10.3390/molecules14010046

来源: mdpi

【 摘 要 】

In this study, the antioxidant activities of 15 flavonoids against lard oil oxidation were determined by using the Rancimat test. Quercetin, dihydromyricetin, luteolin and kaempferol showed the strongest antioxidant activity, with protection factor values (PF) of 11.50, 11.29, 4.24 and 2.49, respectively. The role of conjugated hydroxyl groups of the B and C ring is discussed. By using the following descriptors: ΔH_f (the difference in heat of formation between flavonoids and their free radicals resulted after hydrogen atom donation) and H_BC (the number of conjugated hydroxyl groups of the B and C ring), the result obtained in the antioxidant Rancimat test could be successfully explained.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.