期刊论文详细信息
Molecules
Total Synthesis and the Biological Activities of (±)-Norannuradhapurine
Surachai Nimgirawath1  Rujee Lorpitthaya1  Asawin Wanbanjob1  Thongchai Taechowisan2 
[1] Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom 73000, Thailand; E-mails:;Department of Microbiology, Faculty of Science, Silpakorn University, Nakorn Pathom 73000, Thailand; E-mail:
关键词: Alkaloid;    Anti-inflammatory Activity;    Aporphine;    Isoquinoline;    Synthesis;    Radical Cyclization.;   
DOI  :  10.3390/molecules14010089
来源: mdpi
PDF
【 摘 要 】

The structure previously assigned to the phenolic noraporphine alkaloid, (‑)‑norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (±)-norannuradhapurine inhibits the production of NO, PGE2, TNF-a, IL-1b and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

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