Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

Molecules

Yi-Sheng Xu¹  Cheng-Chu Zeng¹  Zi-Guo Jiao¹  Li-Ming Hu¹ 

[1] College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing 100124, P. R. China

关键词: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives;    HIV-1 integrase;    Mg²⁺ binding;    Aryl diketo acids;   

DOI  :  10.3390/molecules14020868

来源: mdpi

【 摘 要 】

4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by ¹H-NMR, ¹³C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.