Pimarane-type Diterpenes: Antimicrobial Activity against Oral Pathogens

Molecules

Thiago S. Porto¹  Rander Rangel¹  Niege A. J. C. Furtado²  Tatiane C. de Carvalho¹  Carlos H. G. Martins¹  Rodrigo C. S. Veneziani¹  Fernando B. Da Costa²  Adriana H. C. Vinholis¹  Wilson R. Cunha¹  Vladimir C. G. Heleno¹ 

[1] Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil;Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil

关键词: Antimicrobial activity;    Pimarane-type diterpenes;    Oral pathogens;    Viguiera arenaria;    Structural requirements.;   

DOI  :  10.3390/molecules14010191

来源: mdpi

【 摘 要 】

Seven pimarane type-diterpenes re-isolated from Viguiera arenaria Baker and two semi-synthetic pimarane derivatives were evaluated in vitro against the following main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, S. mutans, S. mitis, S. sanguinis and Lactobacillus casei. The compounds ent-pimara-8(14),15-dien-19-oic acid (PA); ent-8(14),15-pimaradien-3b-ol; ent-15-pimarene-8b,19-diol; ent-8(14),15-pimaradien-3b-acetoxy and the sodium salt derivative of PA were the most active compounds, displaying MIC values ranging from 2 to 8 μg∙mL^-1. Thus, this class of compounds seems promising as a class of new effective anticariogenic agents. Furthermore, our results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new natural compounds that could be employed in the development of oral care products.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.