Microwave Assisted Reactions of Some Azaheterocylic Compounds

Molecules

Gheorghita Zbancioc¹  Vasilichia Bejan¹  Marian Risca¹  Costel Moldoveanu¹ 

[1] id="af1-molecules-14-00403">“Al. I. Cuza” University of Iasi, Organic Chemistry Department, Bd. Carol 11, 700506 Iasi, Roman

关键词: Microwave N-alkylation;    Imidazole;    Pyrimidine;    Pyridazine;    Phthalazine;   

DOI  :  10.3390/molecules14010403

来源: mdpi

【 摘 要 】

A fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. In some cases, under MW irradiation the yields are also higher. A comparative study of microwave vs. classical conditions (liquid solvents) has been done. Twelve new diazaheterocylic salts of potential practical interest were obtained.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.