Mechanochemical Solvent-Free and Catalyst-Free One-Pot Synthesis of Pyrano[2,3-d]Pyrimidine-2,4(1H,3H)-Diones with Quantitative Yields

Molecules

Sara Mashkouri¹ 

[1] id="af1-molecules-14-00474">Organic Chemistry Research Laboratory, Department of Chemistry, Iran University of Science and Technology, 16846 Tehran, Ir

关键词: Solvent-free reaction;    Barbituric acid;    Pyrimidinediones;    Heterocyclic compounds;    Ball-milling.;   

DOI  :  10.3390/molecules14010474

来源: mdpi

【 摘 要 】

Solvent-free synthesis of pyrano[2,3-d]pyrimidine-2,4(1H,3H)-diones by ball-milling and without any catalyst is described. This method provides several advantages such as being environmentally friendly, using a simple workup procedure, and affording high yields.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.