The Importance of Brain Banks for Molecular Neuropathological Research: The New South Wales Tissue Resource Centre Experience

International Journal of Molecular Sciences

Irina Dedova²  Antony Harding¹  Donna Sheedy¹  Therese Garrick¹  Nina Sundqvist²  Clare Hunt¹  Juliette Gillies² 

[1] The New South Wales Tissue Resource Centre, Discipline of Pathology, The University of Sydney, NSW 2006, Australia. E-Mails:;Schizophrenia Research Institute, Sydney, NSW 2010, Australia. E-Mails:

关键词: Human;    brain bank;    schizophrenia;    alcohol;    postmortem;    molecular neuropathology;    genome;    proteome;    receptor binding;    clinical characterization;   

DOI  :  10.3390/ijms10010366

来源: mdpi

【 摘 要 】

New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading international brain banking facilities, which operates with best practice and quality control protocols. The focus of this tissue collection is on schizophrenia and allied disorders, alcohol use disorders and controls. This review highlights changes in TRC operational procedures dictated by modern neuroscience, and provides examples of applications of modern molecular techniques to study the neuropathogenesis of many different brain disorders.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).