An Adaptable, Portable Microarray Reader for Biodetection

Sensors

Deanna L. Thompson²  Francesca Pearson¹  Cynthia Thomas¹  Rupa Rao²  Dennis Matthews²  Joanna S. Albala²  Sebastian Wachsmann-Hogiu² 

[1] Lawrence Livermore National Laboratory / 7000 East Ave., Livermore, CA 94550, USA; E-Mails:;NSF – Center for Biophotonics Science and Technology, University of California Davis / 2700 Stockton Blvd. Sacramento CA 95817, USA; E-Mails:

关键词: Microarrays;    immunoassays;    protein arrays;    point-of-care diagnostics;    portable microarray reader;   

DOI  :  10.3390/s90402524

来源: mdpi

【 摘 要 】

We have developed an inexpensive portable microarray reader that can be applied to standard microscope slide-based arrays and other array formats printed on chemically modified surfaces. Measuring only 19 cm in length, the imaging device is portable and may be applicable to both triage and clinical settings. For multiplexing and adaptability purposes, it can be modified to work with multiple excitation/emission wavelengths. Our device is shown to be comparable to a commercial laser scanner when detecting both streptavidin-biotin and antibody interactions. This paper presents the development and characterization of a handheld microarray imager and directly compares it with a commercial scanner.

【 授权许可】

CC BY   
© 2009 by the authors; licensee MDPI, Basel, Switzerland