Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

Molecules

Sri Nurestri Abdul Malek¹  Sim Kae Shin¹  Norhanom Abdul Wahab¹ 

[1] ¹Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia ²Institute of Postgraduate Studies, University of Malaya, 50603 Kuala Lumpur, Malaysia ³International University College of Nursing, B-27-6, Block B, Jaya One, No 72A Jalan Universiti, 46000 Petaling Jaya, Selangor, Malaysia

关键词: Pereskia bleo;    Cactaceae;    cytotoxic activity;    cell lines;   

DOI  :  10.3390/molecules14051713

来源: mdpi

【 摘 要 】

Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC₅₀ value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.