Antibacterial Activity of Methyl Gallate Isolated from Galla Rhois or Carvacrol Combined with Nalidixic Acid Against Nalidixic Acid Resistant Bacteria

Molecules

Jang-Gi Choi¹  Ok-Hwa Kang¹  Young-Seob Lee¹  You-Chang Oh¹  Hee-Sung Chae¹  Hye-Jin Jang¹  Dong-Won Shin¹ 

[1]¹Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute, Jeonbuk 570-749, Korea[2] height:6px

[3]"> ²Department of Oriental Medicine Resources, Sunchon National University, Jeonnam 540-742, Korea

关键词: Nalidixic acid-resistant bacteria;    methyl gallate;    carvacrol;    antibacterial activity;    combination;   

DOI  :  10.3390/molecules14051773

来源: mdpi

【 摘 要 】

Methyl gallate is a major component of Galla Rhois, as carvacrol is of oregano essential oils. Both have shown good antibacterial activity against intestinal bacteria. This study investigated the antibacterial activities of nalidixic acid in combination with methyl gallate and carvacrol against nalidixic acid resistant bacteria. The combined effect of nalidixic acid with methyl gallate and carvacrol was evaluated using the checkerboard method to obtain a fractional inhibitory concentration index. The results showed that the combinations of nalidixic acid + methyl gallate/carvacrol improved nalidixic acid resistant pathogenic bacteria inhibition with synergy or partial synergy activity. Thus, a strong bactericidal effect of the drug combinations was observed. In vitro data thus suggested that nalidixic acid combined with methyl gallate and carvacrol may be microbiologically beneficial, rather than antagonists.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.