Efficient One-Pot Synthesis of Indol-3-yl-Glycines via Uncatalyzed Friedel-Crafts Reaction in Water

Molecules

Mehdi Ghandi¹ 

关键词: Amino acid;    Indol-3-yl-glycine;    Glyoxalic acid;    Friedel-Crafts reaction;   

DOI  :  10.3390/molecules14031056

来源: mdpi

【 摘 要 】

The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.