Protein-Protein Interaction Analysis by Docking

Algorithms

Florian Fink¹  Stephan Ederer² 

[1] Institute of Functional Genomics, University of Regensburg, Josef-Engert-Strasse 9, D-93053 Regensburg, Germany; E-Mail

关键词: Protein-protein docking;    verification of protein interactions;    3D protein structures;   

DOI  :  10.3390/a2010429

来源: mdpi

【 摘 要 】

Based on a protein-protein docking approach we have developed a procedure to verify or falsify protein-protein interactions that were proposed by other methods such as yeast-2-hybrid assays. Our method currently utilizes intermolecular energies but can be expanded to incorporate additional terms such as amino acid based pair-potentials. We show some early results that demonstrate the general applicability of our approach.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.