New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum

Marine Drugs

Takeshi Yamada¹  Yasuhide Muroga² 

[1] Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan; E-Mai

关键词: fungus;    marine-fish;    Chaetomium globosum;    cytotoxicity;    chaetomugilins;    azaphilones;    chemical transformation;    alkaline degradation;   

DOI  :  10.3390/md7020249

来源: mdpi

【 摘 要 】

Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.