Label-Free Electrical Detection Using Carbon Nanotube-Based Biosensors

Sensors

Kenzo Maehashi¹ 

关键词: label-free biosensors;    carbon nanotube;    prostate-specific antigen;    microfludic chips;    field-effect transistors;    aptamer;    IgE;   

DOI  :  10.3390/s90705368

来源: mdpi

【 摘 要 】

Label-free detections of biomolecules have attracted great attention in a lot of life science fields such as genomics, clinical diagnosis and practical pharmacy. In this article, we reviewed amperometric and potentiometric biosensors based on carbon nanotubes (CNTs). In amperometric detections, CNT-modified electrodes were used as working electrodes to significantly enhance electroactive surface area. In contrast, the potentiometric biosensors were based on aptamer-modified CNT field-effect transistors (CNTFETs). Since aptamers are artificial oligonucleotides and thus are smaller than the Debye length, proteins can be detected with high sensitivity. In this review, we discussed on the technology, characteristics and developments for commercialization in label-free CNT-based biosensors.

【 授权许可】

CC BY   
© 2009 by the authors; licensee MDPI, Basel, Switzerland