DNA Sensors with Diamond as a Promising Alternative Transducer Material

Sensors

Veronique Vermeeren²  Sylvia Wenmackers¹  Patrick Wagner¹ 

[1] Institute for Materials Research, School for Life Sciences, Hasselt University and Transnationale Universiteit Limburg, Wetenschapspark 1, B-3590 Diepenbeek, Belgium; E-Mail:;Biomedical Research Institute, School for Life Sciences, Hasselt University and Transnationale Universiteit Limburg, Agoralaan, Bldg. C, B-3590 Diepenbeek, Belgium; E-Mail:

关键词: DNA;    single nucleotide mismatch;    aptamers;    bioconjugates;    biosensors;    impedance sensors;    SPR;    fluorescence sensors;   

DOI  :  10.3390/s90705600

来源: mdpi

【 摘 要 】

Bio-electronics is a scientific field coupling the achievements in biology with electronics to obtain higher sensitivity, specificity and speed. Biosensors have played a pivotal role, and many have become established in the clinical and scientific world. They need to be sensitive, specific, fast and cheap. Electrochemical biosensors are most frequently cited in literature, often in the context of DNA sensing and mutation analysis. However, many popular electrochemical transduction materials, such as silicon, are susceptible to hydrolysis, leading to loss of bioreceptor molecules from the surface. Hence, increased attention has been shifted towards diamond, which surpasses silicon on many levels.

【 授权许可】

CC BY   
© 2009 by the authors; licensee MDPI, Basel, Switzerland