The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations

International Journal of Molecular Sciences

Magdalena Cieślik¹  Anna Mertas⁵  Anna Morawska-Chochólł²  Daniel Sabat³  Rajmund Orlicki¹  Aleksander Owczarek⁴  Wojciech Król⁵ 

[1] Chair and Department of Stomatological Material Science, Pl. Akademicki 17, 41 907 Bytom, Medical University of Silesia, Katowice, Poland; E-Mail:;Department of Biomaterials, Faculty of Materials Science and Ceramics, Al. Mickiewicza 30, 30 059 Cracow, AGH University of Science and Technology, Cracow, Poland; E-Mail:;Department and Institute of Pathomorphology, 3maja 13-15, 41 800 Zabrze, Medical University of Silesia, Poland; E-Mail:;Division of Statistics, Ostrogórska 30, 95 010 Sosnowiec, Medical University of Silesia, Katowice, Poland; E-Mail:;Chair and Department of Microbiology and Immunology, Jordana 19, 41 808 Zabrze, Medical University of Silesia, Katowice, Poland; E-Mails:

关键词: composites;    PLGA co-polymer;    carbon fibers;    hydroxyapatite;    human osteoblast-like cells;    cytotoxicity;    in vivo experiments on animals;    biocompatibility;   

DOI  :  10.3390/ijms10073224

来源: mdpi

【 摘 要 】

Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). The cytotoxicity of the evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during the one-year contact of the assessed materials with living osseous tissue, the progress of bone formation was analyzed and the accompanying process of the materials’ degradation was evaluated. The materials under evaluation proved to be biocompatible.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.