Genistein Inhibition of Topoisomerase IIα Expression Participated by Sp1 and Sp3 in HeLa Cell

International Journal of Molecular Sciences

Najing Zhou¹  Yunli Yan¹  Wenling Li¹  Yanling Wang¹  Lifen Zheng¹  Shuo Han¹  Yongxin Yan¹ 

[1] Cell Biology Division, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, Hebei, China; E-Mails:

关键词: genistein;    topoisomerase II-α;    specificity protein 1 (Sp1);    specificity protein 3 (Sp3);   

DOI  :  10.3390/ijms10073255

来源: mdpi

【 摘 要 】

Genistein (4′, 5, 7-trihydroxyisoflavone) is an isoflavone compound obtained from plants that has potential applications in cancer therapy. However, the molecular mechanism of the action of genistein on cancer cell apoptosis is not well known. In this study, we investigated the effect of genistein on topoisomerase II-α (Topo IIα), an important protein involved in the processes of DNA replication and cell proliferation. The results revealed that inhibition of Topo IIα expression through the regulation of Specificity protein 1 and Specificity protein 3 may be one of the reasons for genistein’s induction of HeLa cell apoptosis.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.