GroEL-Assisted Protein Folding: Does It Occur Within the Chaperonin Inner Cavity?

International Journal of Molecular Sciences

Victor V. Marchenkov¹ 

[1]Institute of Protein Research, Russian Academy of Sciences, 142290, Russian Federation, Pushchino, Moscow Region, Institutskaya street, 4, Russia

[2] E-Mai

关键词: chaperones;    GroEL/ES chaperonin system;    protein folding;    protein aggregation;   

DOI  :  10.3390/ijms10052066

来源: mdpi

【 摘 要 】

The folding of protein molecules in the GroEL inner cavity under the co-chaperonin GroES lid is widely accepted as a crucial event of GroEL-assisted protein folding. This review is focused on the data showing that GroEL-assisted protein folding may proceed out of the complex with the chaperonin. The models of GroEL-assisted protein folding assuming ligand-controlled dissociation of nonnative proteins from the GroEL surface and their folding in the bulk solution are also discussed.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.