Phenoxypropylamines: Synthesis and Antiulcer Evaluation

Molecules

Hui Zhang²  Bao-Yan Zhang²  Qian-Yun Zhang¹  Dong-Mei Zhao³ 

[1] School of Public Health, China Medical University, Shenyang 110001, China; E-mail:;College of Sciences, Northeast University, Shenyang 110004, China; E-mail:;School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; E-mail:

关键词: roxatidine;    synthesis;    antiulcer agents;    phenoxypropylamine;    biological activity;   

DOI  :  10.3390/molecules14051818

来源: mdpi

【 摘 要 】

We have synthesized a number of phenoxypropylamines from N-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}chloroacetamide (3). All the products have been characterized by elemental analysis, ¹H-NMR and MS. The biological activity effects of the title compounds were examined. From the biological activity results, we found that two of them showed significant gastric acid antisecretory activity.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.