Sesquiterpenes from Laurencia similis

Molecules

Hua Su¹  Da-Yong Shi¹  Jing Li¹  Shu-Ju Guo¹  Li-Li Li¹  Zhao-Hui Yuan¹ 

[1] ¹Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China ²Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

关键词: Laurencia similis;    sesquiterpenes;    cytotoxic assay;   

DOI  :  10.3390/molecules14051889

来源: mdpi

【 摘 要 】

One new sesquiterpene, (4E)-1-bromo-5-[(1'S*,3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1(10)-en-9-ol (13), aristolan-1(10),8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC₅₀ > 10 μg/mL).

【 授权许可】

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